Rods and Rings Antinuclear Antibody Pattern in Non Hepatitis C Patients: A Series of Five Cases with Review of Literature
Published: September 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/44960.14020
Mahendra Kumar, Yashwant Kumar, Biman Saikia, Seema Chhabra, Shankar Naidu, Vishal Sharma, Varun Dhir, Ranjana Walker Minz
1. Assistant Professor, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
2. Additional Professor, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
3. Professor, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
4. Assistant Professor, Department of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
5. Assistant Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
6. Associate Professor, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
7. Additional Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
8.
Correspondence
Dr. Mahendra Kumar,
Room No. 29, 4th Floor, Department of Immunopathology, Research Block-A, PGIMER,
Sector-12, Chandigarh, India.
E-mail: drbindmahendra@gmail.com
Antinuclear Antibody (ANA) is commonly found in various Autoimmune Diseases (AD) and their pattern help in narrowing down the differential diagnosis. International Consensus on ANA Pattern (ICAP) has recently introduced Rods and Rings (RR) pattern in their reporting guideline. Since its first identification, it has been considered to be exclusively associated with hepatitis C and its associated treatment {Ribavirin/Interferon-α (INF-α)}. However, later on, a few reports have described its association with other diseases and even in healthy population. In the present series, out of 25,242 clinical samples, five cases of RR-ANA pattern in non hepatitis patients were found and they were further investigated for their disease associations. We are documenting association of RR-ANA pattern with amoebiasis, hepatitis B, idiopathic thrombocytopenic purpura, Rheumatoid Arthritis (RA) and undifferentiated connective tissue disease. Documentation of such reports may help in better understanding of pathobiology and clinical relevance of this pattern.
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